What is endothelium?(Part 4)

Ways of preventing injury to the endothelium

Avoiding or stopping smoking

One of the products of smoking is nicotine, and this substance injures the endothelium which ultimately leads to atherogenesis. Specifically, smoking promotes the oxidation of the low-density lipoprotein (LDL) which—aside from decreasing the concentration of nitric oxide {Consult Powertec (149)}—promotes the migration of the white blood cells (monocytes) in the midst of endothelium, thereby injuring it[1]. Hence, avoid, or stop, smoking as soon as possible.

Simplified steps in protecting your endothelium

  • Consult a medical doctor and have your blood pressure checked;
  • If your blood pressure is elevated, your medical doctor will prescribe youwith medication(s). If so, take them regularly. After two weeks or one month, go back to your medical doctor, and have your blood pressure checked again. If your blood pressure is still high, he will add another medication. If already controlled, he will advise you to continue your medication(s);
  • If you have elevated blood pressure, aside from giving you the necessary medication(s), your medical doctor will request you to have blood chemistry examination, complete blood count, and urinalysis.The blood chemistry examination will consist of the fasting blood sugar, blood urea nitrogen, creatinine, uric acid, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the lipid profile. The lipid profile, in turn, will consist of the total blood cholesterol and triglyceride, high-density lipoprotein, low-density lipoprotein, and the vey low-density lipoprotein;
  • The lipid profile test is very important because it will tell you if you need additional medication(s). If your total cholesterol, and/or your total triglyceride, and/or your LDL cholesterol is (are) high, you need to take drug belonging to the statins. If the predominant elevation falls on the triglycerides, you need to take drug under fenofibrates;
  • If your fasting blood sugar is elevated, it is possible that you are suffering fromdiabetes mellitus. Initially, your medical doctor may design for you dietary therapy and try it for some months. If it does not work after giving a try, you will be prescribed with anti-diabetic drug(s).
  • If your blood pressure is elevated and/or you have abnormalities with your blood lipids and/or your blood sugar is elevated, you need to be very careful with your diet. Avoid high salt and high fat diet. Avoid taking simple carbohydrates like candies, chocolates, sugar, ice cream, and soft drinks. Limit your intake of rice to one cup per meal, and take a lot of foods rich in fibers, such as corn, vegetables, fruits, and cereals;
  • Have a regular and periodic physical exercises. If you are over 50 years old, a 30-minute walking, three times per week, will do you a lot of good! If you are below 50 years old, you can do more than what is prescribed for the elderly. In addition to walking, you can run and you can do bicycling;
  • Stop, or avoid, smoking.

Implement preventive measures with dispatch

The secret of successful preventive measures is to implement them as early as possible. The moment you realized that you have hypertension, and/or hyperlipidemia, and/or diabetes mellitus, you need to start implementing all the measures that have been enumerated in the preceding. The reason for this is that as you withhold doing the preventive actions, complications of the disease have been setting in. Physically, you will not feel it (them)! However, in the recesses of your different organs, such as your heart, kidneys, and blood vessels—be it small, medium, or large—structural destructions have been going on! By the time you want to do something, it is too late! Hence, act without delay!

(End of a series of 4)


  1. Powell JT. Vascular damage from smoking: disease mechanisms at the arterial wall. Vasc Med. 1998;3(1):21-8.http://www.ncbi.nlm.nih.gov/pubmed/9666528.
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